Experimental Biology 2019 - Tang Prize Lecture

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Official Webiste http://experimentalbiology.org/2019/home.aspx
Event Experimental Biology 2019
Time April 6-9, 2020
Location Orlando, Florida, USA
Early Registration Before February 5, 2019
Advanced Registration Before March 20, 2019
Full-price Registration March 21- April 9, 2019 
Time and Venue for the Tang Prize Award Lecture 6p.m., Saturday, April 6, 2019  
Speaker Dr. Brian J. Druker,
2018 Tang Prize Winner for Biopharmaceutical Science
Title Imatinib as a Paradigm of Targeted Cancer Therapies
Lecture Outline Abl is a tyrosine kinase, the gene of which upon translocation to a different chromosomal site (Bcr [breakpoint cluster region]) becomes constitutively active. In addition to Abl, Gleevec also inhibits Kit, PDGF and other tyrosine kinase oncoproteins. It has been useful in the treatment of acute lymphocytic leukemia (ALL) and certain types of gastrointestinal stromal tumors (GISTs) where Kit is overexpressed. Now there are more than 29 TKIs which have been approved for clinical use. Clearly, Dr. Druker’s first successful trials heralded this still burgeoning targeted therapy era. Dr. Druker was also involved in the development of the 4G10 antibody (at Thomas Robert’s lab) which recognizes phosphotyrosine and was used by Novartis colleagues in the screening of Gleevec. Thus, Dr. Druker’s contributions are in both the development and application of Gleevec, which was the first successful example of tyrosine kinase-targeted therapy by small molecule inhibitors.