To fund a series of pilot projects on LNP development for nucleic acid delivery. Data generated from successful pilot studies will be leveraged in larger grant applications in order to fund one or more comprehensive and large-scale research programs on rational design and therapeutic uses of LNP systems.

In the current proposal, we aim to introduce a potentially novel mode of combat against opportunistic pathogenic fungal infections. Specifically, to design, develop, validate, and extensively characterize mRNA-based anti-Candida and anti-Mucor vaccines.

To clarify how blockade of IL-6 receptor signaling has effects on both inflammation and coagulation cascade activation.