Regulation of gut hormone secretion. Studies with isolated perfused organ preparations.

Origin: The Tang Prize is awarded on a biennial basis, each with a cash reward of NT$40 million. Projects proposed by the laureates also receive a grant of up to NT$10 million. The 2024 grant for Biopharmaceutical Science is shared between Professor Joel Habener, Professor Svetlana Mojsov, and Professor Jens Juul Holst.

Project Summary: This project examines gut hormone secretion using isolated perfused organ models that preserve endocrine structure and enable physiologically relevant stimulation. With a focus on GLP-1's therapeutic potential for obesity and type 2 diabetes, this approach bridges single-cell and in vivo studies. Previous work mapped hormone responses to glucose, amino acids, bile acids, and short chain fatty acids. Planned experiments will analyze GLP-1, GIP, PYY, GLP-2, neurotensin, secretin, and IL-5, targeting transporters, receptors, and microbiome-related stimuli. The goal is to develop non-surgical strategies that replicate the hormonal benefits observed after bariatric surgery.