Efficacy of Anti-IL-6 receptor (Tocilizumab) treatment in several types of Cytokine Release Syndrome

A- | A+
Plan information
Project Term: 2021-2023
Budget: About NT$3.3 million

Origin: The Tang Prize is awarded on a biennial basis, each with a cash reward of NT$40 million. Projects proposed by the laureates also receive a grant of up to NT$10 million. The 2020 grant for Biopharmaceutical Science is shared between Dr. Charles Dinarello, Dr. Marc Feldmann and Dr. Tadamitsu Kishimoto.

Project Summary
: Analyze the molecular mechanism on how IL-6 signals function in vascular vessel during cytokine storms. We will identify the precise molecular mechanisms of IL-6 receptor signaling on vascular vessel cells and will find out a new target or strategies to cure cytokine release syndromes.